This is the title of a Robert Heinlein novel about time travel to a better place. It is a Parkinson's Disease (PD) treatment metaphor for me, and this is my progress report.
Great writeup! My father is affected, I'm not (as of yet?) but as part of me throwing sinks at my depressive tendencies, I've had lots of psychedelics, which has HELPED. Some of them demostrably help neuroinflammation (psylocybin, DMT) plus push of neuroplasticity - what's not to like?
Also, you're in the gym a lot. Are you also doing a lot of cardio? Anecdotally, Klimer had a friend who lost all his PD symptoms when cycling all summer. When they stopped riding, they came back, but as soon as he started up again, symptoms were all but gone.
Hyperion Herbs has high-quality lion's mane and Duanwood reishi. Dragon Herbs is another great company for tonic herbs. Quality herbs should taste good!
I saw some good testimonials on YouTube for NAD+ IVs for Parkinson's. I believe they are hormetic, similar to chlorine dioxide and ozone therapy. They stress the mitochondria in a certain way. See Springfield Recovery Center in Louisiana I think or anywhere that offers BR NAD+. Some places offer NAD+ and ketamine together like Klarity Klinics with many locations.
Maybe contact Dragon Herbs about your issues. They have really amazing licensed herbalists who will consider your case for free if you have a customer account. This was THE most effective thing we did when healing my husband's cirrhosis. Their products are extremely well-sourced and powerful. I think they have some products for nerve growth. I've found their advice extremely helpful over the years. Their formulas are life-changing.
You are likely under-dosing the TTFD (B1), at only 200 mg. I don't have Parkinson's but I need 4-600 mg to alleviate my own symptoms.
Eliot Overton (he makes one of the only two TTFDs outside of Japan) says people often need 600 mg and even anything up to 1800 mg (rarely) to see results.
He also mentions these key nutritional cofactors:
- Magnesium – essential for thiamine-utilising enzymes.
- Potassium – helps manage heart rate, blood pressure changes, and fatigue onset with thiamine.
I think there's a problem with one of the links in your piece. I wanted to order the magnesium threonate powder, but did not realize it took me to Bulk Supplements l-threonine powder on Amazon, which I ordered. Since all Bulk Supplements packaging looks the same, I did not realize the error until I had opened it. I subsequently looked at all the Bulk Supplements offerings for magnesium on Amazon, and none were what you seemed to be recommending. Since l-threonine is an amino acid, I doubt that's what you intended. I just thought you ought to know. (I did eventually find some on eBay that was affordable and relatively additive-free: 200g for about $35.)
I found this post very interesting. You have a very generous spirit andare so very forthcoming with your experience. I am sharing this with my daughter who is a Physicians Assistant and she'll most likely share it with her supervising Physician (it is an integreative/wholistic practice). I am archiving this one for future reference. My youngest sister passed away with complications of PD several years ago. Her doctors at Emory University (Atlanta, GA). She had surgeries, and every conventional drug/treatment known to man. She lived with PD for decades, but she was diagnosed very young in her mid-thirties. Thank you , Dr. Yoho.
I think it was an act of Divine Intervention that led me to Dr. Yoho's substack because it has become one of my "go to" places for online health information since I discovered it. His other writings and books are excellent as well and I am particularly grateful for "Judas Dentistry" which is the absolute best rundown of the crimes committed by these charlatans.
Anyway, it's been five years since I had a doctor that I actually trusted but she didn't last long once CVD struck- she quit the profession in disgust and decided to become a farmer.
I live in the suburbs of NYC and it is impossible to find a halfway decent doctor or dentist. At this point I get my best medical advice from the Substack docs like Dr. Yoho, AMD, McCullough, Kory, et al. It is well worth the price of a subscription which has saved me many thousands in medical expenses that would have been incurred because of the quackery that masquerades as medicine these days.
My questions for Dr. Yoho:
1. How do you keep track of all the supplements and treatments you take? Do you take the same ones every day? Do you have a schedule or a regimen that you use?
2. Can you discuss hormone replacement therapy for menopausal women and what are your recommendations in this regard?
3. I have bad varicose veins in one leg that I would like to have surgically removed. Of course I am terrified even of this procedure which supposedly can be done in a doctor's office. Any suggestions?
4. Finally- my sister is in constant pain due to arthritis, bad knees and back problems. She needs to lose weight but even that won't be enough as they want her to get knee replacements. Do you have any recommendations for pain killers or other therapies?
Many thanks! Any information would be appreciated.
Dr. Yoho, This is completely off topic, but I have developed breast pain (possible capsular contracture from implants) Do you think DMSO might help? I have searched till I'm exhausted and really would like to avoid surgery for now.
I'd like to add to the vanilla, homeopath, etc protocol I've set up for myself.
I forgot to mention that last year I felt some dragging of the left leg again. I couldn't make heads or tails of it and why it was acting up.
Then, days later, , I was rushed by ambulance to the hospital with a 9/10 type of pain. I passed a huge kidney stone. [later confirmed by CT and urinalysis]
This was of my own making.
Being into low carb, for months, I had been eating a lot of almond butter and spinach - ironically, the two highest foods [on the order of 300% higher than others] in oxalates.
Thankfully the horrific pain lasted only an hour since on the way to the hospital my friend shoved two pellets of a specific homeopathic remedy in my mouth and the SECOND they hit my tongue the pain stopped cold. I looked at her and smiled. The EMT guy looked at me, perplexed at how my pain had subsided just like that.
Anyhow, there is a small, but direct correlation from steady Oxalate sensitivity, to Parkinson's. Apparently, research shows that oxalates over time, degrade brain cells. Suffice to say, I'm not eating those foods anymore [just foods with very low oxalates - like walnuts] and have no symptoms of foot dragging.
All in all the biggest bang for my buck is the homeopathy - a well-placed remedy was instrumental in the slowing down of my progression and eventual eradication of symptoms. Oxalate reduction, addition of vanillin, fermented kim-chi and yogurts [bio-k specifically] are adjuncts to my protocol. I'm super low in Vitamin D [being here in Canada], and take cod liver oil [slow processed, cold pressed] from Norway, NOT vitamin D pills. I don't need other protocols as I feel our bodies can be overburdened by them.
Again, this is not medical advice. Just anecdotal. Please do your own research. These worked for me. There are some universal truths out there - but also some individualized treatment protocols. An oncologist once told me: "patients have to be their own best advocates".
My latest detox experience has totally changed my perspective on root causes. Also the case studies and the experiences of others in the program. I’m starting to believe the real root of chronic anything is mycotoxins. These have to be fixed first to make any kind of progress. Mycotoxins are unique from other fungals and have to be treated differently. Sinclair Kennelly and Michael Spandel don’t use pharmaceuticals. Nutrients, binders and natural therapies that have worked for me better than anything I’ve tried. Therapies that worked 20, 10, even 5 years ago don’t work anymore. They even have to tweak therapies they used 2 years ago. Now my fasting glucose has dropped 25 points. Resting heart rate also dropped 20 points! No supplements or protocols have touched these previously. these started changing within 2 days with nebulizing with ozonated glycerin and using Navage with biotixin binders to clear elements from sinus and lungs. I didn’t think I had any issues with either. No symptoms.
I’ve tried many protocols that have made me worse. Most detox protocols have. 6 years ago, I spent $10,000 on a year long health coaching program that created oxalate problems and left me malnourished. I’m sure you have had similar experiences!
Nothing in the last 16 years of my health journey has moved the needle this much in such a short time. Spandel says protocols for chronic disease and pain don’t work well until you treat mycotoxins first, then the other protocols are successful. Possibly mycotoxins are why when we treat root causes they aren’t really the root of the problem? Is there a person who has no mycotoxins?
Honokiol, a compound found in Magnolia bark, shows promise as a potential therapeutic agent for Parkinson's disease due to its neuroprotective and neurotrophic effects. Studies in animal models suggest honokiol can reduce oxidative stress, improve motor function, and protect dopamine-producing neurons, all of which are affected in Parkinson's. Furthermore, honokiol may also enhance the effectiveness of levodopa, a common Parkinson's medication, by inhibiting its breakdown in the gut.
How Honokiol May Help with Parkinson's:
Neuroprotective Effects:
Honokiol has been shown to protect nerve cells from damage caused by oxidative stress, a key factor in Parkinson's.
Improved Motor Function:
Studies in animal models indicate that honokiol can improve motor symptoms associated with Parkinson's, such as tremors and rigidity.
Dopamine Neuron Protection:
Parkinson's is characterized by the loss of dopamine-producing neurons. Honokiol has been shown to protect these neurons from degeneration.
Enhanced Levodopa Effectiveness:
Honokiol may inhibit the breakdown of levodopa by gut bacteria, potentially increasing the amount of levodopa available for the brain.
Modulation of α-synuclein:
Honokiol can reduce the levels of α-synuclein, a protein that accumulates abnormally in Parkinson's.
Anti-inflammatory Properties:
Honokiol may also help reduce inflammation in the brain, another factor implicated in Parkinson's progression.
Research and Future Directions:
Animal Studies:
Numerous studies in animal models of Parkinson's have demonstrated the potential benefits of honokiol.
Human Studies:
While promising, more research, including clinical trials, is needed to confirm the safety and efficacy of honokiol in humans with Parkinson's.
Delivery Methods:
Researchers are also exploring ways to improve the delivery and effectiveness of honokiol, such as creating conjugates with short-chain fatty acids (SCFAs).
Potential Side Effects:
Honokiol has a limited side effect profile, but it is important to consider its potential antithrombotic effects, particularly in individuals with clotting disorders.
I admire your persistence… you will find something that works! If you haven’t looked into honokiol it might something that can help as it has shown promise in treating PD. Good luck!
Robert, are you taking DHA, Omega3 in larger quantities??? That would be the first thing I'd start with... You can take algae oil, if you do not like fish... DHA/EPA, but in particular DHA, that's like No1 brain ingredient, responsible for LOT of functions there, here some literature on it in connection with PD:
oh, for fungus, depending on type though, a mix of EO's: Tea tree oil, you can add lavender, blue chamomile and thyme, if tea tree does not do the job on its own..
it is called LumoraBeam, a compact at-home device designed to eliminate nail fungus using low-level laser therapy (LLLT)—a method trusted by experts and clinics alike...
Wow, thanks for the article Doc. I have many of the same issues as you but not all. My father died from PD and I’m scared to death I will get it. So far so good, but I’m still terrified. It was an ugly and early death. He died at 78 and I’m only 73 but he was a mess after 75. I’ve got your book Butchered by Health Care, but I haven’t read it yet. I think this article will motivate me. I’ve got your hormone book as well. I’ve worked out all my life and all I have to show for it is worn out joints some of which have been replaced and the rest hurt, although the replaced joints didn’t work out all that well either.
Great writeup! My father is affected, I'm not (as of yet?) but as part of me throwing sinks at my depressive tendencies, I've had lots of psychedelics, which has HELPED. Some of them demostrably help neuroinflammation (psylocybin, DMT) plus push of neuroplasticity - what's not to like?
Many thanks for your work and best regards
Might be of use:
Low doses of cannabis extract ameliorate non-motor symptoms of Parkinson’s disease patients: a case series
https://www.frontiersin.org/journals/human-neuroscience/articles/10.3389/fnhum.2024.1466438/full
Also, you're in the gym a lot. Are you also doing a lot of cardio? Anecdotally, Klimer had a friend who lost all his PD symptoms when cycling all summer. When they stopped riding, they came back, but as soon as he started up again, symptoms were all but gone.
Hyperion Herbs has high-quality lion's mane and Duanwood reishi. Dragon Herbs is another great company for tonic herbs. Quality herbs should taste good!
I saw some good testimonials on YouTube for NAD+ IVs for Parkinson's. I believe they are hormetic, similar to chlorine dioxide and ozone therapy. They stress the mitochondria in a certain way. See Springfield Recovery Center in Louisiana I think or anywhere that offers BR NAD+. Some places offer NAD+ and ketamine together like Klarity Klinics with many locations.
Maybe contact Dragon Herbs about your issues. They have really amazing licensed herbalists who will consider your case for free if you have a customer account. This was THE most effective thing we did when healing my husband's cirrhosis. Their products are extremely well-sourced and powerful. I think they have some products for nerve growth. I've found their advice extremely helpful over the years. Their formulas are life-changing.
@Robert Yoho MD
You are likely under-dosing the TTFD (B1), at only 200 mg. I don't have Parkinson's but I need 4-600 mg to alleviate my own symptoms.
Eliot Overton (he makes one of the only two TTFDs outside of Japan) says people often need 600 mg and even anything up to 1800 mg (rarely) to see results.
He also mentions these key nutritional cofactors:
- Magnesium – essential for thiamine-utilising enzymes.
- Potassium – helps manage heart rate, blood pressure changes, and fatigue onset with thiamine.
- B-complex vitamins – prevent imbalance by supporting interconnected pathways (B2, B3, B5, B6, folate, B12).
His "Thiamax" (note spelling) is pure TTFD (B1) with no excipients (fillers):
https://www.objectivenutrients.com/products/
(His Thiaviate B-Complex is also excellent)
Overton interviewed Daphne Bryan, author of "Parkinson's and the B1 Therapy" here
https://www.youtube.com/watch?v=iuSOQOTyB9w
But honestly these two videos have more information:
Dr Ruscio interview with Eliot Overton
https://www.youtube.com/watch?v=-we9gMcdRe8
Dr. Izabella Wentz interview with Eliot Overton
https://www.youtube.com/watch?v=Asu2IwCGgzI
I think there's a problem with one of the links in your piece. I wanted to order the magnesium threonate powder, but did not realize it took me to Bulk Supplements l-threonine powder on Amazon, which I ordered. Since all Bulk Supplements packaging looks the same, I did not realize the error until I had opened it. I subsequently looked at all the Bulk Supplements offerings for magnesium on Amazon, and none were what you seemed to be recommending. Since l-threonine is an amino acid, I doubt that's what you intended. I just thought you ought to know. (I did eventually find some on eBay that was affordable and relatively additive-free: 200g for about $35.)
I found this post very interesting. You have a very generous spirit andare so very forthcoming with your experience. I am sharing this with my daughter who is a Physicians Assistant and she'll most likely share it with her supervising Physician (it is an integreative/wholistic practice). I am archiving this one for future reference. My youngest sister passed away with complications of PD several years ago. Her doctors at Emory University (Atlanta, GA). She had surgeries, and every conventional drug/treatment known to man. She lived with PD for decades, but she was diagnosed very young in her mid-thirties. Thank you , Dr. Yoho.
I think it was an act of Divine Intervention that led me to Dr. Yoho's substack because it has become one of my "go to" places for online health information since I discovered it. His other writings and books are excellent as well and I am particularly grateful for "Judas Dentistry" which is the absolute best rundown of the crimes committed by these charlatans.
Anyway, it's been five years since I had a doctor that I actually trusted but she didn't last long once CVD struck- she quit the profession in disgust and decided to become a farmer.
I live in the suburbs of NYC and it is impossible to find a halfway decent doctor or dentist. At this point I get my best medical advice from the Substack docs like Dr. Yoho, AMD, McCullough, Kory, et al. It is well worth the price of a subscription which has saved me many thousands in medical expenses that would have been incurred because of the quackery that masquerades as medicine these days.
My questions for Dr. Yoho:
1. How do you keep track of all the supplements and treatments you take? Do you take the same ones every day? Do you have a schedule or a regimen that you use?
2. Can you discuss hormone replacement therapy for menopausal women and what are your recommendations in this regard?
3. I have bad varicose veins in one leg that I would like to have surgically removed. Of course I am terrified even of this procedure which supposedly can be done in a doctor's office. Any suggestions?
4. Finally- my sister is in constant pain due to arthritis, bad knees and back problems. She needs to lose weight but even that won't be enough as they want her to get knee replacements. Do you have any recommendations for pain killers or other therapies?
Many thanks! Any information would be appreciated.
DMSO for every bit of it.
I presume you're keeping up with this, Dr Yoho; but, just in case you haven't seen it:
"IVERMECTIN and FENBENDAZOLE SUCCESS STORIES: Parkinson's Disease Cured in 4 Months"
https://www.2ndsmartestguyintheworld.com/p/ivermectin-and-fenbendazole-success-188
Dr. Yoho, This is completely off topic, but I have developed breast pain (possible capsular contracture from implants) Do you think DMSO might help? I have searched till I'm exhausted and really would like to avoid surgery for now.
Yes, if I were you, I would use DMSO topically and orally; it is harmless. Take a tablespoon a day orally in a glass of water. And look at this, too: https://robertyoho.substack.com/p/265-shaher-khan-mdthe-foremost-plastic?utm_source=publication-search
Dr Yoho, there is a reel of you on Instagram! First one I’ve seen. Over 2000 comments.
I can't find it
https://www.instagram.com/reel/DNF30aNAoHV/?igsh=MTMzbWJpOWU1aTdtcA==
@healing.united
Never saw this! Maybe I should start posting...
There are about 5 or 6 different reels. I’ve tried to put you info in the comments for each one.
I guess it’s Christian Elliot, @healthunited that is posting it.
Correction @healing.united
I'd like to add to the vanilla, homeopath, etc protocol I've set up for myself.
I forgot to mention that last year I felt some dragging of the left leg again. I couldn't make heads or tails of it and why it was acting up.
Then, days later, , I was rushed by ambulance to the hospital with a 9/10 type of pain. I passed a huge kidney stone. [later confirmed by CT and urinalysis]
This was of my own making.
Being into low carb, for months, I had been eating a lot of almond butter and spinach - ironically, the two highest foods [on the order of 300% higher than others] in oxalates.
Thankfully the horrific pain lasted only an hour since on the way to the hospital my friend shoved two pellets of a specific homeopathic remedy in my mouth and the SECOND they hit my tongue the pain stopped cold. I looked at her and smiled. The EMT guy looked at me, perplexed at how my pain had subsided just like that.
Anyhow, there is a small, but direct correlation from steady Oxalate sensitivity, to Parkinson's. Apparently, research shows that oxalates over time, degrade brain cells. Suffice to say, I'm not eating those foods anymore [just foods with very low oxalates - like walnuts] and have no symptoms of foot dragging.
All in all the biggest bang for my buck is the homeopathy - a well-placed remedy was instrumental in the slowing down of my progression and eventual eradication of symptoms. Oxalate reduction, addition of vanillin, fermented kim-chi and yogurts [bio-k specifically] are adjuncts to my protocol. I'm super low in Vitamin D [being here in Canada], and take cod liver oil [slow processed, cold pressed] from Norway, NOT vitamin D pills. I don't need other protocols as I feel our bodies can be overburdened by them.
Again, this is not medical advice. Just anecdotal. Please do your own research. These worked for me. There are some universal truths out there - but also some individualized treatment protocols. An oncologist once told me: "patients have to be their own best advocates".
So what sublingual did your friend give you that stopped your pain?
My latest detox experience has totally changed my perspective on root causes. Also the case studies and the experiences of others in the program. I’m starting to believe the real root of chronic anything is mycotoxins. These have to be fixed first to make any kind of progress. Mycotoxins are unique from other fungals and have to be treated differently. Sinclair Kennelly and Michael Spandel don’t use pharmaceuticals. Nutrients, binders and natural therapies that have worked for me better than anything I’ve tried. Therapies that worked 20, 10, even 5 years ago don’t work anymore. They even have to tweak therapies they used 2 years ago. Now my fasting glucose has dropped 25 points. Resting heart rate also dropped 20 points! No supplements or protocols have touched these previously. these started changing within 2 days with nebulizing with ozonated glycerin and using Navage with biotixin binders to clear elements from sinus and lungs. I didn’t think I had any issues with either. No symptoms.
I’ve tried many protocols that have made me worse. Most detox protocols have. 6 years ago, I spent $10,000 on a year long health coaching program that created oxalate problems and left me malnourished. I’m sure you have had similar experiences!
Nothing in the last 16 years of my health journey has moved the needle this much in such a short time. Spandel says protocols for chronic disease and pain don’t work well until you treat mycotoxins first, then the other protocols are successful. Possibly mycotoxins are why when we treat root causes they aren’t really the root of the problem? Is there a person who has no mycotoxins?
AI Overview
Honokiol, a compound found in Magnolia bark, shows promise as a potential therapeutic agent for Parkinson's disease due to its neuroprotective and neurotrophic effects. Studies in animal models suggest honokiol can reduce oxidative stress, improve motor function, and protect dopamine-producing neurons, all of which are affected in Parkinson's. Furthermore, honokiol may also enhance the effectiveness of levodopa, a common Parkinson's medication, by inhibiting its breakdown in the gut.
How Honokiol May Help with Parkinson's:
Neuroprotective Effects:
Honokiol has been shown to protect nerve cells from damage caused by oxidative stress, a key factor in Parkinson's.
Improved Motor Function:
Studies in animal models indicate that honokiol can improve motor symptoms associated with Parkinson's, such as tremors and rigidity.
Dopamine Neuron Protection:
Parkinson's is characterized by the loss of dopamine-producing neurons. Honokiol has been shown to protect these neurons from degeneration.
Enhanced Levodopa Effectiveness:
Honokiol may inhibit the breakdown of levodopa by gut bacteria, potentially increasing the amount of levodopa available for the brain.
Modulation of α-synuclein:
Honokiol can reduce the levels of α-synuclein, a protein that accumulates abnormally in Parkinson's.
Anti-inflammatory Properties:
Honokiol may also help reduce inflammation in the brain, another factor implicated in Parkinson's progression.
Research and Future Directions:
Animal Studies:
Numerous studies in animal models of Parkinson's have demonstrated the potential benefits of honokiol.
Human Studies:
While promising, more research, including clinical trials, is needed to confirm the safety and efficacy of honokiol in humans with Parkinson's.
Delivery Methods:
Researchers are also exploring ways to improve the delivery and effectiveness of honokiol, such as creating conjugates with short-chain fatty acids (SCFAs).
Potential Side Effects:
Honokiol has a limited side effect profile, but it is important to consider its potential antithrombotic effects, particularly in individuals with clotting disorders.
I admire your persistence… you will find something that works! If you haven’t looked into honokiol it might something that can help as it has shown promise in treating PD. Good luck!
https://caringsunshine.com/relationships/relationship-parkinsons-disease-and-honokiol/?srsltid=AfmBOoqiJkbXn5frQTdA1UdegMXO3M42fZr5Cgpd-K1TqqiybSpV4jMA
Robert, are you taking DHA, Omega3 in larger quantities??? That would be the first thing I'd start with... You can take algae oil, if you do not like fish... DHA/EPA, but in particular DHA, that's like No1 brain ingredient, responsible for LOT of functions there, here some literature on it in connection with PD:
https://www.sciencedirect.com/science/article/pii/S2667268524000214
https://pmc.ncbi.nlm.nih.gov/articles/PMC6747747/
https://onlinelibrary.wiley.com/doi/full/10.1111/jnc.16154
https://www.sciencedirect.com/science/article/abs/pii/B978032391747600007X
oh, for fungus, depending on type though, a mix of EO's: Tea tree oil, you can add lavender, blue chamomile and thyme, if tea tree does not do the job on its own..
what about krill
oh, just saw this, so pasting it here for U:
https://nailfungussolution.com/trending/this-is-how-people-around-the-world-are-finally-clearing-nail-fungus-without-risky-medications-or-painful-surgeries
it is called LumoraBeam, a compact at-home device designed to eliminate nail fungus using low-level laser therapy (LLLT)—a method trusted by experts and clinics alike...
yes, forgot to mention the BEST one indeed;)
Wow, thanks for the article Doc. I have many of the same issues as you but not all. My father died from PD and I’m scared to death I will get it. So far so good, but I’m still terrified. It was an ugly and early death. He died at 78 and I’m only 73 but he was a mess after 75. I’ve got your book Butchered by Health Care, but I haven’t read it yet. I think this article will motivate me. I’ve got your hormone book as well. I’ve worked out all my life and all I have to show for it is worn out joints some of which have been replaced and the rest hurt, although the replaced joints didn’t work out all that well either.
read DMSO section in the Apocalypse Almanac; it is the bomb for aging athletes and start testosterone
Ok, I have tried Amazon, I’ve tried to google it and I can’t find it, is that a chapter or a publication? Thanks for the help.
https://robertyoho.substack.com/p/yohos-apocalypse-almanac-da6